منابع مشابه
Protein folding rates correlate with heterogeneity of folding mechanism.
By observing trends in the folding kinetics of experimental 2-state proteins at their transition midpoints, and by observing trends in the barrier heights of numerous simulations of coarse-grained, C(alpha) model Go proteins, we show that folding rates correlate with the degree of heterogeneity in the formation of native contacts. Statistically significant correlations are observed between fold...
متن کاملDetermine folding mechanism of Lali structure, northern Dezful, Zagros, Iran
Lali sub-surface structure, with a NW-SE Zagros trending is located in Dezful Embayment. To determine the folding mechanism, structural geometric parameters including limbs dip, amplitude, wavelength, and crestal length were determined in four stages during deformation. In order to investigate the lateral folding mechanism, these geometric parameters were analyzed in three parts in the Lal...
متن کاملProtein folding and misfolding: mechanism and principles.
Two fundamentally different views of how proteins fold are now being debated. Do proteins fold through multiple unpredictable routes directed only by the energetically downhill nature of the folding landscape or do they fold through specific intermediates in a defined pathway that systematically puts predetermined pieces of the target native protein into place? It has now become possible to det...
متن کاملProtein Stability, Folding, Disaggregation and Etiology of Conformational Malfunctions
Estimation of protein stability is important for many reasons: first providing an understanding of the basic thermodynamics of the process of folding, protein engineering, and protein stability plays important role in biotechnology especially in food and protein drug design. Today, proteins are used in many branches, including industrial processes, pharmaceutical industry, and medical fields. A...
متن کاملDissecting the folding mechanism of the outer membrane protein PagP
Introduction The E.coli outer membrane (OM) is densely packed with outer membrane proteins (OMPs) that carry out a diverse range of functions that include (non)specific transport of small and large ligands, proteolytic and synthetic reactions and cellular recognition and adhesion. However, despite their importance, understanding the biogenesis of OMPs and their folding and insertion into membra...
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ژورنال
عنوان ژورنال: Kagaku To Seibutsu
سال: 1998
ISSN: 0453-073X,1883-6852
DOI: 10.1271/kagakutoseibutsu1962.36.290